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Clonazepam's primary mechanism of action is the modulation of GABA function in the brain, by the benzodiazepine receptor, located on GABA A receptors , which, in turn, leads to enhanced GABAergic inhibition of neuronal firing. Benzodiazepines do not replace GABA, but instead enhance the effect of GABA at the GABA A receptor by increasing the opening frequency of chloride ion channels, which leads to an increase in GABA's inhibitory effects and resultant central nervous system depression. [5] In addition, clonazepam decreases the utilization of 5-HT (serotonin) by neurons [99] [100] and has been shown to bind tightly to central-type benzodiazepine receptors. [101] Because clonazepam is effective in low milligram doses ( mg clonazepam = 10 mg diazepam), [102] it is said to be among the class of "highly potent" benzodiazepines . [103] The anticonvulsant properties of benzodiazepines are due to the enhancement of synaptic GABA responses, and the inhibition of sustained, high-frequency repetitive firing. [104]

Carlos Gardel was to tango what Elvis was to rock 'n' roll. He is probably the most prominent figure in the history of ballroom dance. A new house museum, the Museo Casa Carlos Gardel , celebrates his legendary years in Buenos Aires, and you can pay your respects to him at the Cementerio la Chacarita . If you want to give tango a whirl, head to the Centro Cultural Torquato Tasso , a serious venue in which respected artists perform regularly. If you prefer to dip and swirl members of the same sex, then the gay milongas are the place to be. La Marshall and Tango Entre Muchachos are excellent venues for queer tango.

The ‘Palace Greatly Blessed by Heaven’, as its name (Gyeongbokgung) means, has the longest and most storied history of any Korean palace, with a story that starts in 1395, three years after the beginning of Joseon Dynasty rule. Later kings of the Joseon Dynasty continued to expand the palace, but much of it was destroyed during a slave rebellion in 1592. Fast-forward to 1867, when the palace buildings were reconstructed. The new structures, over 330 in all, made up a massive complex with 5,792 rooms, taking up 4,414,000 square feet (410,000 square metres) of land. Today, about 40per cent of Gyeongbokgung’s original buildings exist. The absence of those that are no more have made some room for walking – and the massive crowds. This is the most-visited place in all Korea by foreign tourists, and locals love it as well, even more so since the unveiling of the reconstructed front gate, Gwanghwamun, in 2010. Gyeongbokgung Royal Palace . Open Mar- Oct 9am-6pm Mon, Wed-Sun. Nov-Feb 9am-5pm Mon, Wed-Sun. English-language guided tours 11am, , . Admission ₩3,000. Sejongno 1-1 (3700-3900). Transport: Gyeongbokgung station (line 3), exit 5.

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