Prepare reliable aqueous, organic, and biomolecular samples with membrane filtration inside a polypropylene (PP) housing. Each housing comes with a color-coded retainer ring seal to prevent leaks and sample loss, and the color helps to visually show you the membrane type inside the housing.
Syringe filters have Luer-Lok and Luer-slip connections for easy, quick and tight connections to tubing, syringes, or needles. Filter packs are available in a resealable storage container to prevent contamination during multiple opening and closings.
The life of the syringe is directly related to its cleanliness. To clean syringes, it is best to use solvents known to be effective in solvating the sample—preferably those that are non-alkaline, non-phosphate, and non-detergent based. High-quality water and good-grade acetone prove to be good rinses. To clean the plunger, remove it from the syringe barrel and gently wipe it with a lint-free tissue. Reinsert the plunger into the barrel and pump deionized water or acetone through the needle and syringe. Air dry the syringe for storage. When reinserting a PTFE-tipped plunger into a syringe barrel, lubricate the tip by wetting it with deionized water or another solvent compatible with the sample.
The pharmacokinetics of abatacept in RA patients and healthy subjects appeared to be comparable. In RA patients, after multiple intravenous infusions, the pharmacokinetics of abatacept showed proportional increases of C max and AUC over the dose range of 2 mg/kg to 10 mg/kg. At 10 mg/kg, serum concentration appeared to reach a steady state by day 60 with a mean (range) trough concentration of 24 mcg/mL (1 to 66 mcg/mL). No systemic accumulation of abatacept occurred upon continued repeated treatment with 10 mg/kg at monthly intervals in RA patients.