Nonsteroidal antiandrogen

Bicalutamide has not been approved for use as monotherapy.

In one phase II clinical trial with bicalutamide used as a single agent, breast tenderness, breast swelling, and hot flashes were reported in %, %, and % of treated patients, respectively.

Another phase II clinical trial with bicalutamide used as a single agent reported breast pain, and gynecomastia in 76% and 60% of treated patients, respectively. This study also showed generalized pain in 30% of treated patients, hot flashes in 28%, pelvic pain in 26%, and libido decrease and impotence, both at 25%. [ Ref ]

A nonsteroidal antiandrogen ( NSAA ) is an antiandrogen with a nonsteroidal chemical structure . [1] [2] They are typically selective and full or silent antagonists of the androgen receptor (AR) and act by directly blocking the effects of androgens like testosterone and dihydrotestosterone (DHT). [1] [2] NSAAs are used in the treatment of androgen-dependent conditions in men and women. [1] They are the converse of steroidal antiandrogens (SAAs), which are antiandrogens that are steroids and are structurally related to testosterone. [1] [2]

Nonsteroidal antiandrogen

nonsteroidal antiandrogen

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