Fight the misery of biting fleas with Advantage II! This convenient, easy to apply monthly topical kills fleas through contact, so they don’t have to bite your cat to die. Fleas don’t just make your cat itchy, they keep biting and hurting again and again. If a flea is ingested it can also cause tapeworms. Advantage II kills adult and immature stages of fleas, thereby effectively breaking the flea life cycle and preventing flea infestations. Since fleas can be brought into your home by you or other pets without even realizing it, it is important to treat indoor pets too. Remember, if your cat has fleas, you have fleas!*
For beginning EpiModel users and those new to mathematical modeling
generally, EpiModel includes two web-based applications for simulating
epidemics, using the Shiny
framework in R. These applications are included within EpiModel
for deterministic compartmental models (DCMs), stochastic individual
contact models (ICMs), and stochastic network models. They are also hosted
online at the links below.
DCMs ICMs Network
In clinical practice, vaccine doses occasionally are administered at intervals less than the minimum interval or at ages younger than the minimum age. Doses administered too close together or at too young an age can lead to a suboptimal immune response. However, administering a dose a limited number of days earlier than the minimum interval or age is unlikely to have a substantially negative effect on the immune response to that dose. Therefore, ACIP recommends that vaccine doses administered 4 or fewer days before the minimum interval or age be counted as valid. However, because of its unique schedule, this recommendation does not apply to the rabies vaccine ( 9 ). Doses administered 5 or more days earlier than the minimum interval or age of any vaccine should not be counted as valid doses and should be repeated as age-appropriate. The repeat dose should be spaced after the invalid dose by the recommended minimum interval ( Table 1 ). For example, if Haemophilus influenzae type b (Hib) doses one and two were administered only 2 weeks apart, because the minimum interval from dose one to dose two is 4 weeks, dose two is invalid and should be repeated. The repeat dose should be administered 4 or more weeks after the invalid (second) dose. The repeat dose would be counted as the second valid dose. Doses administered 5 or more days before the minimum age should be repeated on or after the child reaches the minimum age and 4 or more weeks after the invalid dose. For example, if the first dose of varicella vaccine were administered at age 10 months, the repeat dose would be administered no earlier than the child's first birthday. If the first dose of varicella vaccine were administered at age 11 months and 2 weeks, the repeat dose could be administered 2 weeks after the first birthday.