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Corticosteroids have been used as drug treatment for some time. Lewis Sarett of Merck & Co. was the first to synthesize cortisone, using a complicated 36-step process that started with deoxycholic acid, which was extracted from ox bile . [43] The low efficiency of converting deoxycholic acid into cortisone led to a cost of US $200 per gram. Russell Marker , at Syntex , discovered a much cheaper and more convenient starting material, diosgenin from wild Mexican yams . His conversion of diosgenin into progesterone by a four-step process now known as Marker degradation was an important step in mass production of all steroidal hormones, including cortisone and chemicals used in hormonal contraception . [44] In 1952, . Peterson and . Murray of Upjohn developed a process that used Rhizopus mold to oxidize progesterone into a compound that was readily converted to cortisone. [45] The ability to cheaply synthesize large quantities of cortisone from the diosgenin in yams resulted in a rapid drop in price to US $6 per gram, falling to $ per gram by 1980. Percy Julian's research also aided progress in the field. [46] The exact nature of cortisone's anti-inflammatory action remained a mystery for years after, however, until the leukocyte adhesion cascade and the role of phospholipase A2 in the production of prostaglandins and leukotrienes was fully understood in the early 1980s.

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Steroid cream muscle pain

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Relieve Aches and Pain Without Harmful Side Effects If you are suffering from pain and inflammation from a ligament strain or sprain, try Overtime Pain Relief Lotion ® to improve your function, reduce inflammation and help temporarily relieve minor aches and pains from your underlying muscle, arthritis, joint, neck and back pain symptoms. Overtime Pain Relief Lotion ® is a clinically tested safe and effective pain lotion developed by a UCLA-trained medical doctor, who specializes in the treatment of patients with acute and chronic pain conditions. Our unique formula combines seven natural, scientifically proven pain relieving ingredients and anti-inflammatory agents with enhanced skin penetrants using a specialized process that shrinks the lotion’s particle size to allow our formula to penetrate deeper and faster into aching tissue for fast, long-lasting relief. No other topical pain product has been proven to be stronger than Overtime Pain Relief Lotion. Overtime Pain Relief Lotion is an FDA registered over-the-counter product that’s available to you direct without a prescription, manufactured in the USA in an FDA-Certified Lab, and recommended by physicians across America.

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