Vitamin d3 steroid

A United States Institute of Medicine report states: "Outcomes related to cancer , cardiovascular disease and hypertension , and diabetes and metabolic syndrome, falls and physical performance, immune functioning and autoimmune disorders , infections, neuropsychological functioning, and preeclampsia could not be linked reliably with calcium or vitamin D intake and were often conflicting." [56] : 5 Some researchers claim the IOM was too definitive in its recommendations and made a mathematical mistake when calculating the blood level of vitamin D associated with bone health. [57] Members of the IOM panel maintain that they used a "standard procedure for dietary recommendations" and that the report is solidly based on the data. Research on vitamin D supplements, including large-scale clinical trials, is continuing. [57]

Rodents are somewhat more susceptible to high doses than other species, and cholecalciferol has been used in poison bait for the control of these pests. It has been claimed that the compound is less toxic to non-target species. However, in practice it has been found that use of cholecalciferol in rodenticides represents a significant hazard to other animals, such as dogs and cats. "Cholecalciferol produces hypercalcemia, which results in systemic calcification of soft tissue, leading to renal failure, cardiac abnormalities, hypertension, CNS depression, and GI upset. Signs generally develop within 18-36 hr of ingestion and can include depression, anorexia, polyuria, and polydipsia." [32]

Edit:
Lost my train of thought sorry:
Regarding the warning label–because the body breaks down D2 over a 24-48 hour period, the half life of D2 is 60 hours (5 days), you only take the large dose (usualy 50K IU) once a week. taking it any sooner would result in a build up and cause a strain on both your Liver and your kidneys as they try to process out the excess. This can lead to both liver damage, kidney stones, kidney failure, and other NASTY issues.
Bottom line. If you are taking D2, take it as prescribed if it is in a High Dose–ANYTHING OVER 5000 IU is considered a HIGH DOSE of D2 or Ergocalciferol (if reading it on a vitamin lablel.
The RDA for D3 is 600 IU max daily.
The RDA for D2 is 350 IUmax daily

Structural relationship of vitamin D 3 (cholecalciferol) and vitamin D 2 (ergocalciferol) with their respective provitamins, cholesterol, and a classic steroid hormone, cortisol (see inset box). The two structural representations presented at the bottom for both vitamin D 3 and vitamin D .2 are equivalent; these are simply different ways of drawing the same molecule. It is to be emphasized that vitamin D 3 is the naturally occurring form of the vitamin; it is produced from 7-dehydrocholesterol, which is present in the skin, by the action of sunlight (see Figure 2). Vitamin D 2 (which is equivalently potent to vitamin D 3 in humans and many mammals, but not birds) is produced commercially by the irradiation of the plant sterol ergosterol with ultraviolet light.

New Roles of Vitamin D3
"Initially thought to play a restricted role in calcium homeostasis, the pleiotropic actions of vitamin D in biology and their clinical significance are only now becoming apparent. However, the mode of action of vitamin D, through its cognate nuclear vitamin D receptor (VDR), and its contribution to diverse disorders, remain poorly understood. We determined VDR binding throughout the human genome using chromatin immunoprecipitation followed by massively parallel DNA sequencing (ChIP-seq). After calcitriol stimulation, we identified 2776 genomic positions occupied by the VDR and 229 genes with significant changes in expression in response to vitamin D."

Vitamin d3 steroid

vitamin d3 steroid

Structural relationship of vitamin D 3 (cholecalciferol) and vitamin D 2 (ergocalciferol) with their respective provitamins, cholesterol, and a classic steroid hormone, cortisol (see inset box). The two structural representations presented at the bottom for both vitamin D 3 and vitamin D .2 are equivalent; these are simply different ways of drawing the same molecule. It is to be emphasized that vitamin D 3 is the naturally occurring form of the vitamin; it is produced from 7-dehydrocholesterol, which is present in the skin, by the action of sunlight (see Figure 2). Vitamin D 2 (which is equivalently potent to vitamin D 3 in humans and many mammals, but not birds) is produced commercially by the irradiation of the plant sterol ergosterol with ultraviolet light.

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